Dihydrotestosterone (DHT) is a potent and highly energetic androgen implicated for men pattern hair loss. Dihydrotestosterone is produced mostly in the prostate gland, examen, adrenal glands and tresses follicles. The formation of dihydrotestosterone involved testosterone as a prohormone. Testosterone is digested by either of the two types of isoenzymes: 5-alpha reductase type I actually and 5-alpha reductase type II changing it to a more active dihydro- form.
Androgen target cells are the sites of dihydrotestosterone formation which include the androgen dependent and androgen sensitive regions in the body. In the androgen sensitive region, the nuclear membrane and microsomes take part in the conversion process. Although, testosterone is produced mainly in the souffrance, production of dihydrotestosterone masteron occurs any place in the body where testosterone has entered the cells of the vom männlichen geschlechtshormon dependent tissue. Within the scalp, the androgen dependent areas include the frontotemporal region, the crown and the vertex. Essentially, these are web sites where hair tumble occurs at the beginning of male pattern hair loss.
Dihydrotestosterone and Man Pattern Hair Loss
Within the androgen dependent areas on the scalp, androgenic hormone or testosterone is transformed into dihydrotestosterone. Dihydrotestosterone then binds to the androgen receptors in the hair follicles. The vom männlichen geschlechtshormon receptors actually bind both testosterone and dihydrotestosterone. However, the dihydro- form has higher affinity to and dissociates more slowly from the receptors. Thus, higher levels of the body hormone are retained in the receptors. The existence of the androgens in the hair follicles actually helps hair growth. However, in genetically predisposed individuals, high levels of DHT can prevent hair growth, even completely stopping it. As a result, the afflicted area on the scalp slowly but surely thins and may turn completely bald. Also if baldness has not yet occurred, the influenced may still look balding because of progressive miniaturization of hair. Normally, this type of hair reduction commences during puberty where the body produces high levels of testosterone.
Dihydrotestosterone can only exert their negative effects on susceptible individuals. Male pattern tresses loss is heritable. Individuals who inherit the gene that predisposes the situation become susceptible to the action of DHT. They are prone to experience hair losing during puberty nonetheless they might not exactly really notice it until after thirty where significant quantity of hair was lost. The condition influences more than 50 % of men, but the same condition is also determined in women.
At present, the male design hair loss has no cure. Affected individuals, however, can find treatments that can stop hair reduction effectively. Since the role of DHT has already been recognized and widely accepted, the suggested treatment for the condition is the one which addresses the situation with DHT. The DHT levels on the scalp should be maintained at levels where it cannot harm the hair follicles. This can be created by instituting treatments that block the creation of the hormone such as treatments that inhibit the enzyme that catalyzes the conversion process. Typically the drugs minoxidil and finasteride are known as DHT blockers because they work mainly by blocking the conversion process. Both drugs are proven effective in stopping male pattern hair loss. They might also decide for natural treatments that blocks DHT and encourages hair regrowth.